![]() Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients. baclofen drug reversal, alcohol withdrawal syndrome treatment, hepatic encephalopathy, cannabis toxicity, etc.) For this reason, there are several non-FDA approved uses (eg. However, flumazenil also works to reverse non-benzodiazepine substances that interact with GABA/benzodiazepine receptor complex. Method of Action:Flumazenil is a benzodiazepine antagonist. MAX cumulative: The LOWEST of 1 mg or 0.05 mg/kg Initial dose: 0.01 mg/kg (MAX 0.2 mg) given over 15 secondsįollowed by: Same dose every 1 minute for up to 4 additional doses. Pediatric greater than or equal to 1 year old: Pharmacology, adverse reactions, warnings and side effects. If sedation reoccurs: 0.2 mg IV may be given at 20-minute intervals Flumazenil prescription and dosage sizes information for physicians and healthcare professionals. Head injuries or altered cerebral blood flowīenzodiazepine reversal can provoke panic attacks in those with panic disorders Patients exhibiting signs of tricyclic antidepressants overdose ![]() Reversal of benzodiazepines may provoke convulsions/seizures in: Toxicity would most likely manifest as seizures, dysrhythmias, and hypotension ![]() Overdose/Toxicity – overdose of flumazenil is extremely rare and wouldn’t be expected in a patient that does NOT have a benzodiazepine dependence. Those receiving Romazicon should be monitored for at least 2 hours. MAX cumulative: The LOWEST of 1 mg or 0.05 mg/kg Classification: Benzodiazepine Antagonist Method of Action: Flumazenil is a benzodiazepine antagonist. Seizure risk – reversal of benzodiazepines can result in seizures, especially in those who use benzodiazepines to manage seizures. Initial dose: 0.01 mg/kg (MAX 0.2 mg) given over 15 seconds Followed by: Same dose every 1 minute for up to 4 additional doses. 5 mg IV total cumulative dose for suspected benzodiazepine overdose. This suggest possible antagonism of inhaled anesthetics or even restorative affects of the drug itself.Įxpiration – Flumazenil is only stable for 24 hours if drawn into a syringe or mixed with LR, NS, or D5W Max dose for reversal of conscious sedation is 1 mg IV.
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